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    Stroke / Neuro Critical Care

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    Further protocol information can be found on the links below at ClinicalTrials.gov


    Active Trials

    Title: Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial
    Description: A multicenter, randomized, controlled clinical trial of 1400 patients that will include approximately 60 enrolling sites. The study hypotheses are that treatment of hyperglycemic acute ischemic stroke patients with targeted glucose concentration (80mg/dL - 130 mg/dL) will be safe and result in improved 3 month outcome after stroke
    Investigator: Nobl Barazangi, MD
    Eligibility: Subjects, 18 years of age and older, must be within 12 hours of stroke symptom onset and have diabetes and glucose concentrations of over 110 mg/dL on initial evaluation
    Status: Active and open to enrollment
    Contact: Katie Ponting, 415-600-1163, Email: PontinK@cpmcri.org about Study SHINE

    Title: A Phase 2 Double Blinded, Randomized, Placebo Controlled Dose Escalation Study to Evaluate the Efficacy and the Safety of GM602 in Patients With Acute Middle Cerebral Artery Ischemic Stroke Within an 18-hour Treatment Window
    Description: Efficacy and Safety Study of GM602 in Patients With Acute Middle Cerebral Artery Ischemic Stroke Within 18 Hours (GMAIS)
    Investigator: Nobl Barazangi, MD
    Eligibility: Subjects with Acute Middle Cerebral Artery Ischemic Stroke who can be treated within an 18-hour treatment window
    Status: Active and open to enrollment
    Contact: Katie Ponting, 415-600-1163, Email: PontinK@cpmcri.org about Study GMAIS

    Title: Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial
    Description: Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial
    Investigator: Nobl Barazangi, MD
    Eligibility: 18 years of age and older with the ability to randomize within 12 hours of symptom onset
    Status: Active and open to enrollment
    Contact: Katie Ponting, 415-600-1163, Email: PontinK@cpmcri.org about Study POINT

    Title: Expanding the Time Window for IV Thrombolysis with rt-PA in Acute Ischemic Stroke Patients Using Computed Tomography Perfusion Imaging: The PERFusion Use in Stroke Evaluation (PERFUSE) Study
    Description: Patients with ischemic stroke who can be treated within six hours of symptom onset
    Investigator: Nobl Barazangi, MD
    Eligibility: Acute Ischemic Stroke (AIS) patients, ≥ 18 years old, who present up to 6 hours from time of onset of acute stroke symptoms
    Status: Active and open to enrollment
    Contact: Katie Ponting, 415-600-1163, Email: PontinK@cpmcri.org about Study PERFUSE

    • updated February 2014

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