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    Stroke / Neuro Critical Care

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    Further protocol information can be found on the links below at ClinicalTrials.gov


    Active Trials

    Title: Diffusion Weighted Imaging (DWI) or Computerized Tomography Perfusion (CTP) Assessment With Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention (DAWN Study)
    Description: The purpose of the study is to evaluate the hypothesis that Trevo thrombectomy plus medical management leads to superior clinical outcomes at 90 days as compared to medical management alone in appropriately selected subjects experiencing an acute ischemic stroke when treatment is initiated within 6-24 hours after last seen well.
    Co-Investigator: Nobl Barazangi, MD, PhD
    Co-Investigator: Joey English, MD
    Eligibility: Subjects 18 years of age and older with clinical signs and symptoms consistent with the diagnosis of an acute ischemic stroke
    Status: Active and open to enrollment
    Contact: Douglas Raggett, RN, 415-600-3777, Email: RaggettD@cpmcri.org about Study DAWN

    Title: Stryker Neurovascular Trevo® Retriever Registry
    Description: The purpose of the Trevo® Retriever Registry is to collect real world performance data of the Trevo Retriever which is intended to restore blood flow in the neurovasculature by removing thrombus in patients experiencing ischemic stroke
    Investigator: Joey English, MD
    Eligibility: Subjects experiencing acute ischemic stroke who are eligible for restoration of blood flow using any approved Trevo Retriever in the neurovasculature to remove thrombus
    Status: Active and open to enrollment
    Contact: Wilson Ling, 415-600-3148, Email: LingW@cpmcri.org about Study Trevo Retriever

    Title: Expanding the Time Window for IV Thrombolysis with rt-PA in Acute Ischemic Stroke Patients Using Computed Tomography Perfusion Imaging: The PERFusion Use in Stroke Evaluation (PERFUSE) Study
    Description: Patients with ischemic stroke who can be treated within six hours of symptom onset
    Investigator: Nobl Barazangi, MD
    Eligibility: Acute Ischemic Stroke (AIS) patients, ≥ 18 years old, who present up to 6 hours from time of onset of acute stroke symptoms
    Status: Active and open to enrollment
    Contact: Katie Ponting, 415-600-1163, Email: PontinK@cpmcri.org about Study PERFUSE

    Title: COMPASS Trial: a Direct Aspiration First Pass Technique
    Description: This is a prospective, randomized trial comparing mechanical thrombectomy with the ADAPT approach to stent retrievers in patients presenting with AIS within 6 hours of symptom onset
    Investigator: Joey English, MD
    Eligibility: Subjects, 18 y/o and older, with acute ischemic stroke, NIHSS ≥8 at the time of neuroimaging and persistent symptoms within 6 hours of when groin puncture can be obtained
    Status: Active and open to enrollment
    Contact: Douglas Raggett, RN, 415-600-3777, Email: RaggettD@cpmcri.org about Study COMPASS

    Title: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled 21-Day Treatment Study, Including an fMRI Sub-Study, to Evaluate the Effect of HT-3951 on Upper Extremity Motor Function Following Ischemic Stroke (RESTORE)
    Description: This is a randomized, double-blind, placebo-controlled parallel group outpatient study that will utilize standard stroke rehabilitation outcome measures, as well as fMRI techniques in a subset of subjects, to evaluate the effect of HT-3951 on motor recovery and behavior in medically stable subjects following ischemic stroke
    Investigator: Scott Rome, MD
    Eligibility: Subjects, 40 to 85 y/o, who have experienced an ischemic stroke documented by CT or MRI with size of the lesion ≤ 60 cc resulting in an upper extremity deficit that, in the opinion of the Investigator, warrants the need for rehabilitation therapy
    Status: Active and open to enrollment
    Contact: Melissa Machado, 415-600-3709, Email: MachaM@sutterhealth.org about Study DART RESTORE

    • updated October 2016

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