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    Further protocol information can be found on the links below at ClinicalTrials.gov


    Gastroparesis / Gastric Motility  |  Esophageal Disorders


    Active Trials

    Gastroparesis / Gastric Motility

    Title: A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Phase 2 Study to Assess the Efficacy, Safety, and Tolerability of Velusetrag for the Treatment of Diabetic or Idiopathic Gastroparesis
    Decscription: This study will explore the efficacy and safety of multiple doses of velusetrag in the treatment of symptoms in subjects with diabetic or idiopathic gastroparesis
    Investigator: Lauren Gerson, MD, MSc
    Eligibility: Subjects aged 18 to 75 years old who have symptoms of gastroparesis (eg, nausea, early satiety, fullness, bloating, upper abdominal pain, retching or vomiting) for at least 3 months prior to screening
    Status: Active and open to enrollment
    Contact: Juliana Ma, 415-600-1368, Email: MaJX@cpmcri.org about Study Theravance 0099

    Title: Use of Domperidone for Treatment of Upper Gastrointestinal Disorders
    Decscription: This study is to provide oral domperidone to patients where, according to the investigator's judgment, a prokinetic effect is needed for the treatment of refractory symptoms from gastroparesis, functional dyspepsia, or gastroesophageal reflux disease.
    Investigator: Lauren Gerson, MD, MSc
    Eligibility: Subjects 18 years of age and older with symptoms of gastrointestinal disorders
    Status: Active and open to enrollment
    Contact: Lauren Gerson, MD, MSc, 415-674-5200, Email: GersonL@cpmcri.org about Study Domperidone

    Title: GpR 2: Continuation of the NIDDK Gastroparesis Registry for the Characterization and Clinical Course of Gastroparesis Patients
    Decscription: The Gastroparesis Registry (GpR) is a study to clarify the epidemiology, natural history, clinical course, and other outcomes of gastroparesis.
    Investigator: William Snape, MD
    Eligibility: Subjects aged 18 to 70 years old with symptoms of gastroparesis
    Status: Active and open to enrollment
    Contact: Candice Lee, 415-600-1155, Email: LeeCL@cpmcri.org about Study Gastroparesis Registry

    Title: Aprepitant for the Relief of Nausea in Patients With Chronic Nausea and Vomiting of Presumed Gastric Origin: A Multicenter, Randomized, Double-Masked, Placebo-Controlled Trial
    Decscription: Aprepitant for the Relief of Nausea in Patients With Chronic Nausea and Vomiting of Presumed Gastric Origin Trial (APRON)
    Investigator: William Snape, MD
    Eligibility: Subjects with nausea and vomiting presumed to be of gastric origin
    Status: Active and open to enrollment
    Contact: Candice Lee, 415-600-1155, Email: LeeCL@cpmcri.org about Study APRON

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    Esophageal Disorders

    Title: Wide Area Transepithelial Sample Esophageal Biopsy combined with computer assisted 3-dimensional analysis (WATS) For the Detection of Esophageal Dysplasia: A Prospective, Randomized, Tandem Study
    Decscription: The primary purpose of this clinical trial is to evaluate a new diagnostic test, Wide Area Transepithelial Sample Esophageal Biopsy (WATS) with 3-Dimensional computer assisted method of analysis, as an adjunct in the detection of esophageal dysplasia
    Investigator: Lauren Gerson, MD, MSc
    Eligibility: Subjects 18 years of age and older who have a history of Barrett's esophagus (with or without dysplasia of either indefinite, low grade or high-grade)
    Status: Active and open to enrollment
    Contact: Juliana Ma, 415-600-1368, Email: MaJX@cpmcri.org about Study WATS

    Title: Randomized Controlled Trial of Botulinum Toxin Injection for Patients with Spastic Esophageal Motor Disorders
    Decscription: This study is to assess whether injection of botulinum toxin A is more effective compared to placebo for symptom relief in patients presenting with nutcracker esophagus, diffuse esophageal spasm and/or hypertensive lower esophageal sphincter
    Investigator: Lauren Gerson, MD, MSc
    Eligibility: Subjects 18 to 90 years old with symptoms of chest pain, dysphagia, and/or heartburn/regurgitation for at least 3 months’ duration
    Status: Active and open to enrollment
    Contact: Juliana Ma, 415-600-1368, Email: MaJX@cpmcri.org about Study Botox

    • updated March 2015

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