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    Further protocol information can be found on the links below at ClinicalTrials.gov


    Gastroparesis / Gastric Motility  |  Esophageal Disorders


    Active Trials

    Gastroparesis / Gastric Motility

    Title: A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Phase 2 Study to Assess the Efficacy, Safety, and Tolerability of Velusetrag for the Treatment of Diabetic or Idiopathic Gastroparesis
    Description: This study will explore the efficacy and safety of multiple doses of velusetrag in the treatment of symptoms in subjects with diabetic or idiopathic gastroparesis
    Investigator: Lauren Gerson, MD, MSc
    Eligibility: Subjects aged 18 to 75 years old who have symptoms of gastroparesis (eg, nausea, early satiety, fullness, bloating, upper abdominal pain, retching or vomiting) for at least 3 months prior to screening
    Status: Active and open to enrollment
    Contact: Anna von Bakonyi, LVN, 415-600-1107, Email: vonBakA@cpmcri.org about Study Theravance 0099

    Title: Use of Domperidone for Treatment of Upper Gastrointestinal Disorders
    Description: This study is to provide oral domperidone to patients where, according to the investigator's judgment, a prokinetic effect is needed for the treatment of refractory symptoms from gastroparesis, functional dyspepsia, or gastroesophageal reflux disease.
    Investigator: Lauren Gerson, MD, MSc
    Eligibility: Subjects 18 years of age and older with symptoms of gastrointestinal disorders
    Status: Active and open to enrollment
    Contact: Lauren Gerson, MD, MSc, 415-674-5200, Email: GersonL@cpmcri.org about Study Domperidone

    Title: GpR 2: Continuation of the NIDDK Gastroparesis Registry for the Characterization and Clinical Course of Gastroparesis Patients
    Description: The Gastroparesis Registry (GpR) is a study to clarify the epidemiology, natural history, clinical course, and other outcomes of gastroparesis.
    Investigator: William Snape, MD
    Eligibility: Subjects aged 18 to 70 years old with symptoms of gastroparesis
    Status: Active and open to enrollment
    Contact: Candice Lee, 415-600-1155, Email: LeeCL@cpmcri.org about Study Gastroparesis Registry

    Title: Aprepitant for the Relief of Nausea in Patients With Chronic Nausea and Vomiting of Presumed Gastric Origin: A Multicenter, Randomized, Double-Masked, Placebo-Controlled Trial
    Description: Aprepitant for the Relief of Nausea in Patients With Chronic Nausea and Vomiting of Presumed Gastric Origin Trial (APRON)
    Investigator: William Snape, MD
    Eligibility: Subjects with nausea and vomiting presumed to be of gastric origin
    Status: Active and open to enrollment
    Contact: Candice Lee, 415-600-1155, Email: LeeCL@cpmcri.org about Study APRON

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    Esophageal Disorders

    Title: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study of the Efficacy, Safety and Tolerability of Dupilumab in Adult Patients With Active Eosinophilic Esophagitis
    Description: The primary objective of the study is to assess the clinical efficacy of repeat subcutaneous (SC) doses of dupilumab, compared with placebo, to relieve symptoms in adult patients with active, moderate to severe eosinophilic esophagitis (EoE)
    Investigator: Lauren Gerson, MD, MSc
    Eligibility: Subjects 18 years of age and older who have a documented diagnosis of EoE by endoscopy prior to screening
    Status: Active and open to enrollment
    Contact: Juliana Ma, 415-600-1368, Email: MaJX@cpmcri.org about Study Regeneron 1324

    Title: Wide Area Transepithelial Sample Esophageal Biopsy combined with computer assisted 3-dimensional analysis (WATS) For the Detection of Esophageal Dysplasia: A Prospective, Randomized, Tandem Study
    Description: The primary purpose of this clinical trial is to evaluate a new diagnostic test, Wide Area Transepithelial Sample Esophageal Biopsy (WATS) with 3-Dimensional computer assisted method of analysis, as an adjunct in the detection of esophageal dysplasia
    Investigator: Lauren Gerson, MD, MSc
    Eligibility: Subjects 18 years of age and older who have a history of Barrett's esophagus (with or without dysplasia of either indefinite, low grade or high-grade)
    Status: Active and open to enrollment
    Contact: Juliana Ma, 415-600-1368, Email: MaJX@cpmcri.org about Study WATS

    Title: Randomized Controlled Trial of Botulinum Toxin Injection for Patients with Spastic Esophageal Motor Disorders
    Description: This study is to assess whether injection of botulinum toxin A is more effective compared to placebo for symptom relief in patients presenting with nutcracker esophagus, diffuse esophageal spasm and/or hypertensive lower esophageal sphincter
    Investigator: Lauren Gerson, MD, MSc
    Eligibility: Subjects 18 to 90 years old with symptoms of chest pain, dysphagia, and/or heartburn/regurgitation for at least 3 months’ duration
    Status: Active and open to enrollment
    Contact: Juliana Ma, 415-600-1368, Email: MaJX@cpmcri.org about Study Botox

    • updated July 2015

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