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    Cardiology Clinical Trials

    Heart Failure, LVAD & Heart Transplant ProgramOpens new window

    Adult Clinical Trials Main Page

    Further protocol information can be found on the links below at ClinicalTrials.gov


    Active Studies

    PIONEER
    Title: comParIson Of Sacubitril/valsartaN Versus Enalapril on Effect on ntpRo-bnp in Patients Stabilized From an Acute Heart Failure Episode (PIONEER-HF)
    Description: This randomized phase III trial studies how well Sacubitril/valsartan works compared with enalapril in treating patients hospitalized for Acute Decompensated Heart Failure (ADHF)
    Investigator: Michael Pham, MD
    Eligibility: Subjects, 18 y/o and older, currently hospitalized for ADHF, in stable condition, with left ventricular ejection fraction (LVEF) <40% and elevated NT-pro-BNP
    Status: Open to enrollment
    Contact: Jessica Redford, 415-600-1654, Email: redforj@cpmcri.org about the PIONEER-HF Study

    Respirix
    Title: Cardiospire Hemodynamic Correlation Study in Adult Cardiothoracic Surgery Patients
    Description: This prospective, observational study evaluates the relationships between nPAC (non-invasive pulmonary artery compliance) - measured by the CardioSpire device - and pulmonary artery pressure, cardiac output, derived stroke volume, and right atrial pressure - measured by a pulmonary artery catheter
    Investigator: Jared Herr, MD
    Eligibility: Subjects, 18 y/o and older, with scheduled cardiac surgery (including coronary artery bypass graft (CABG), heart transplant, and valve repair or replacement procedures) with expected post-surgery duration on ventilator with indwelling pulmonary artery catheter of at least 6 hours
    Status: Open to enrollment
    Contact: Jessica Redford, 415-600-1654, Email: redforj@cpmcri.org about the Respirix study

    MOMENTUM 3
    Title: MOMENTUM 3 Continued Access Protocol (MOMENTUM 3 CAP)
    Description: This single-arm, prospective, multi-center study evaluates safety and clinical performance of the HeartMate 3 Left Ventricular Assist System
    Investigator: Brett Sheriden, MD
    Eligibility: Subjects, 18 y/o and older, diagnosed with heart failure NYHA Class III with dyspnea upon mild physical activity or NYHA Class IV, with left ventricular ejection fraction (LVEF) <25%
    Status: Open to enrollment
    Contact: Jessica Redford, 415-600-1654, Email: redforj@cpmcri.org about the MOMENTUM Study

    CardioMEMS
    Title: CardioMEMS HF System Post Approval Study
    Description: This post approval study evaluates the use of the CardioMEMS HF System in patients with NYHA class III heart failure in a commercial setting
    Investigator: Jared Herr, MD
    Eligibility: Subjects, 18 y/o and older, with a diagnosis of NYHA class III heart failure and at least 1 heart failure hospitalization within previous 12 months
    Status: Closed to enrollment, follow-up only
    Contact: Jessica Redford, 415-600-1654, Email: redforj@cpmcri.org about the CardioMEMS study

    GALACTIC
    Title: Registrational Study With Omecamtiv Mecarbil/AMG 423 to Treat Chronic Heart Failure With Reduced Ejection Fraction (GALACTIC-HF)
    Description: This double-blind, randomized, placebo-controlled phase III trial studies how well treatment with omecamtiv mecarbil/AMG 423 works compared to a placebo in subjects with chronic Heart Failure with reduced ejection fraction (HFrEF)
    Investigator: Michael Pham, MD
    Eligibility: Subjects, 18 y/o and older, with history of chronic heart failure (HF), left ventricular ejection fraction (LVEF) ≤ 35%, NYHA class II to IV, hospitalized for HF currently or within one year, with elevated BNP or NT-proBNP
    Status: Open to enrollment
    Contact: Jessica Redford, 415-600-1654, Email: redforj@cpmcri.org about the GALACTIC Study

    Title: Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients With AsYmptomatic Severe Aortic Stenosis
    Description: This clinical trial is a prospective, randomized, controlled, multi-center study. Patients will be randomized 1:1 to receive either transcatheter aortic valve replacement (TAVR) with the Edwards SAPIEN 3 THV or clinical surveillance. Patients will be stratified by whether or not they are able to perform a treadmill stress test. Patients who have a positive stress test will be followed in a registry to collect data on subsequent treatment and mortality, as applicable.
    Investigator: David Daniels M.D.
    Eligibility: Male or Female Adults 65 years of older
    Status: Coming Soon
    Contact: Email: redforj@cpmcri.org about the Early TAVR study.

    Updated April 2018