Tracheobronchial Gland Epithelial Cell Lines
Background
Cystic Fibrosis is a genetic disorder that affects the respiratory, digestive and reproductive systems. There are approximately 30,000 people in the United States with CF and approximately 2,500 new cases diagnosed each year. Currently, there is no cure for CF. These cell lines were created as part of an ultimate aim of developing genetic and pharmacological therapies for cystic fibrosis.
Back to top
Applications
These cell lines can be used to determine the role of CFTR, to define therapeutic agents that can correct mutant CFTR function, and to develop therapeutic modalities to treat CF pathology.
Back to top
Advantages
The parental cell line CFSMEo- was derived from preparation of airway bronchial submucosal gland epithelial cell and is immortalized with an origin of replication defective SV 40 virus-containing plasmid. The cells have unlimited growth potential, have tight junctions, and a 
F508/ Q2X CF genotype.
Back to top
Description
Bronchial Epithelial Cell Lines (CFSMEo) - parental cell line.
2005-293
CFSMEo-/CEP-CFTR 4.7: A CF submucosal gland-derived cell line complemented with a 4.7 Kb wild type CFTR cDNA
2005-294
CFSMEo-/CEP-CFTR 6.2: A CF submucosal gland-derived cell line complemented with a 6.2 Kb wild type CFTR cDNA
2005-295
CFSMEo-/CEP-CFTR F4.7: A CF submucosal gland-derived cell line complemented with a 4.7 Kb F508 CFTR cDNA
_______________________________________________
Bronchial Epithelial Cell Lines (6CFSMEo-) - daughter cell line.
2005-299
6CFSMEo-/CEP-CFTR F4.7: A CF submucosal gland-derived cell line complemented with a 4.7 Kb F508 CFTR cDNA
2005-300
6CFSMEo-/CEP-CFTR 4.7: A CF submucosal gland-derived cell line complemented with a 4.7 Kb wild type CFTR cDNA
2005-301
6CFSMEo-/CEP-CFTR 6.2: A CF submucosal gland-derived cell line complemented with a 6.2 Kb wild type CFTR cDNA
Back to top
Patents and Publications
Technology Reference Number
G-101104a
Back to top
> Novel Anticancer Drugs
> Therapeutics for Invasive and Metastatic Cancers
> ClearVisionTM
> Tracheobronchial Gland Epithelial Cell Lines
> Bronchial Epithelial Cell Lines
> Novel Immortal Cell Lines
> Development of Human Cancer Vaccines in Pre-Clinical Mouse Tumor Models
> Cell Lines For The Study of Respiratory Diseases
> Breast Cancer Risk Assessment through Mammographic Density Measurements