Scientist; Director of the CPMCRI Clinical Research Fellowship Program
Karin L. Petersen, MD
Clinical mechanisms underlying neuropathic pain and allodynia; healthy volunteer and acute neuropathic pain states as predictive models for developing new analgesic drugs
Dr. Petersen invented a new human experimental pain model (the heat/capsaicin sensitization model) that is now the standard for testing new analgesic compounds in healthy volunteers. She has extensive experience designing and conducting Phase I to Phase IV trials.
Translational studies in collaboration with CPMCRI’s Dr. Michael Rowbotham assessing clinical symptoms and skin nerve cell functional and anatomical changes following herpes zoster (shingles) have greatly influenced current thinking on neuropathic pain mechanisms and how acute pain becomes chronic.
Actively mentoring pre- and postdoctoral students in clinical and translational research, Dr. Petersen directs CPMCRI’s unique Clinical Research Fellowship Program, with a particular emphasis on U.S. and international medical and predoctoral students.
Dr. Petersen received her M.D. from the University of Copenhagen and completed Advanced Training in Clinical Research (epidemiology and biostatistics) at the University of California at San Francisco (UCSF).
Representative publications include:
- Slagelse C, Petersen KL, Dahl JB, Finnerup K, Greene K, Leong SP, Levine J, Rowbotham M, Werner MU, Finnerup NB. Persistent postoperative pain and sensory changes following lymph node excision in melanoma patients: a topical review. Melanoma Res. 2013 Dec 16.
- Cavallone LF, Frey K, Montana MC, Joyal J, Regina KJ, Petersen KL, Gereau RW 4th. Reproducibility of the heat/capsaicin skin sensitization model in healthy volunteers. J Pain Res. 2013 Nov 7;6:771-84.
- Reda H, Greene K, Rice FL, Rowbotham MC, Petersen KL. Natural history of herpes zoster: late follow-up of 3.9 years (n=43) and 7.7 years (n=10). Pain. 2013 Oct;154(10):2227-33.
- Werner MU, Petersen KL, Rowbotham MC, Dahl JB. Healthy volunteers can be phenotyped using cutaneous sensitization pain models. PLoS One. 2013 May 9;8(5):e62733.
- Campbell CM, Kipnes MS, Stouch BC, Brady KL, Kelly M, Schmidt WK, Petersen KL, Rowbotham MC, Campbell JN. Randomized control trial of topical clonidine for treatment of painful diabetic neuropathy. PAIN; 153 (2012) 1815–1823.
- Jensen-Dahm C, Rowbotham MC, Reda H, Petersen KL. Effect of a single dose of pregabalin on herpes zoster pain. Trials 2011;12:55.
Visit www.cpmcri-currents.org for the latest news about Dr. Petersen's research.