Welcome to the Sarwal Lab
Our lab focuses on translational bedside-to-bench cutting edge research with the use of high throughput technologies such as genomics, metabolomics, proteomics, and deep sequencing to unravel the complex heterogeneity of organ diseases, focusing particularly on the kidney, solid organ transplant rejection and tolerance. The aim of these studies is to identify potentially important diagnostic, prognostic and therapeutic markers for disease monitoring, treatment and prognosis. We have applied our studies to improve outcomes in organ transplantation by a complete steroid avoidance protocol in pediatric kidney transplantation, by identification of blood-based markers to predict acute rejection risk stratification months before histological injury to the organ and to predict which patients will develop chronic transplant injury after renal transplantation.
Minnie Sarwal, MD, FRCP, PhD, DCH
Director, The BIOMARCC Program, CPMC Research Institute
Minnie Sarwal is a highly regarded Medical Professional with over 25 years of clinical experience and 16 years of research experience in the cutting-edge field of translational immunobiology, genomics, proteomics and informatics. She holds a PhD in Molecular Genetics from Cambridge University (Christ's College), under the mentorship of Nobel Laureate Sydney Brenner. She also has a Diploma in Child Health from London, UK and the Membership of the Royal College of Physicians, UK. She was formally elected as a Fellow of the Royal College of Physians, UK in 2009, for her outstanding contributions to the medical field. Dr. Sarwal has been the Director of the Sarwal Lab for the past 14 years, with a staff of 19 researchers, and has previously also been the Medical Director of the clinical pediatric kidney transplant program at LPCH, Stanford University. Dr. Sarwal is nationally and internationally recognized for leadership in the field of renal and transplant medicine, genomics, proteomics and immunology.As principal Investigator for industry and non-industry multicenter clinical trials, she has extensive experience in trial design, execution, and human subject safety policies.
- Sigdel TK, Woo SH, Dai H, Khatri P, Li L, Myers B, Sarwal MM, Lafayette RA.
Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approach.
Clin J Am Soc Nephrol. 2011 Dec;6(12):2775-84.
- Naesens M, Khatri P, Li L, Sigdel TK, Vitalone MJ, Chen R, Butte AJ, Salvatierra O, Sarwal MM.
Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes.
Kidney Int. 2011 Dec;80(12):1364-76. doi: 10.1038/ki.2011.245. Epub 2011 Aug 31.
- Vitalone MJ, Naesens M, Sigdel T, Li L, Hseih S, Sarwal MM.
The dual role of epithelial-to-mesenchymal transition in chronic allograft injury in pediatric renal transplantation.
Transplantation. 2011 Oct 15;92(7):787-95.
- Wei C, El Hindi S, Li J, Fornoni A, Goes N, Sageshima J, Maiguel D, Karumanchi SA, Yap HK, Saleem M, Zhang Q, Nikolic B, Chaudhuri A, Daftarian P, Salido E, Torres A, Salifu M, Sarwal MM, Schaefer F, Morath C, Schwenger V, Zeier M, Gupta V, Roth D, Rastaldi MP, Burke G, Ruiz P, Reiser J.
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis.
Nat Med. 2011 Jul 31;17(8):952-60. doi: 10.1038/nm.2411.
- Dudley JT, Sirota M, Shenoy M, Pai RK, Roedder S, Chiang AP, Morgan AA, Sarwal MM, Pasricha PJ, Butte AJ.
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease.
Sci Transl Med. 2011 Aug 17;3(96):96ra76.
- Li L, Sigdel T, Vitalone M, Lee SH, Sarwal M.
Differential immunogenicity and clinical relevance of kidney compartment specific antigens after renal transplantation.
J Proteome Res. 2010 Dec 3;9(12):6715-21. Epub 2010 Nov 5.
- Rong C, Sigdel T, Li L, Kambham N, Dudley J, Hsieh S, Klassen B, Chen A, Caohuu T, Morgan A, Valantine H, Khush K, Sarwal M, Butte A.
Differentially Expressed RNA from Public Microarray Data Identifies Serum Protein Biomarkers for Cross-Organ Transplant Rejection and Other Conditions.
PLOS Computational Biology