Basic Science Researcher Garret L Yount, PhD
Molecular and cellular biology of cancers, and mind-body approaches to health and well-being
Current research in the Yount lab focuses on understanding cancer cell metastasis; the role of independent motile microplasts in the migration of brain tumor cells; treatment of glioblastoma multiforme with camptothecin and other herbal compounds used in Traditional Chinese Medicine; and evaluating the evidence for a human biofield that can be manipulated to influence healing processes.
Leading the Mind-Body Medicine Research Group and collaborating with the Institute for Health and Healing at CPMC, Dr. Yount studies physiologic and genomic changes associated with stress reduction and positive emotions, and how these changes are affected by novel interventions including music and expressive arts therapy.
Dr. Yount’s lab developed a saliva-based test to measure epigenetic changes in patients non-invasively, and the test is being investigated for use as a diagnostic in pediatric Crohn’s disease.
Dr. Yount studied molecular and cellular biology at Pennsylvania State University, before completing a Ph.D. in Neurobiology and Behavior at the State University of New York at Stony Brook. During his postdoctoral training at the University of California, San Francisco, he was awarded a fellowship from the Robert Steel Foundation for Pediatric Cancer Research.
- Yount G, Mager, J, Moore, D, Bendl, D, Rachlin, K (2008) Evaluating Biofield Treatments in the Laboratory. in Measuring the Immeasurable: The Scientific Case for Spirituality, Compilation copyright, Sounds True Inc., Boulder, CO.
- Vad NM, Yount G, Moridani, MY (2008) Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines. Melanoma Research, 18(6):386-99.
- Yount G, Yang Y, Wong B, Wang HJ, Yang, LX (2007) A Novel Camptothecin Analog with Enhanced Antitumor Activity. Anticancer Research, 27:3173-3178
- Mager J, Bendl D, Luu T, Rachlin K, Moore D, Aldape K, Yount G (2007) Evaluating Biofield Treatments in Cell Culture Model of Oxidative Stress. EXPLORE: The Journal of Science & Healing, 3(4):386-90.
- Yount G, Taft RJ, Luu T, Rachlin K, Moore D, Zhang W (2006). Independent motile microplast formation correlates with glioma cell invasiveness. Journal of Neuro-Oncology, 81(2):113-21.
- Rossi E, Rossi K, Yount G, Cozzolino M, Iannotti S (2006). The Bioinformatics of Integrative Medical Insights: Proposals for an International PsychoSocial and Cultural Bioinformatics Project. Integrative Medicine Insights, 2:7-26.
- Afshar G, Basila D, Furniss S, Yount GL, Arvold ND, Koller E, Haas-Kogan DA (2006). Radiation-induced caspase-8 expression mediates p53-independent apoptosis in glioma cells. Cancer Research, 66:4223-32.
- McAllister SD, Chan C, Taft RJ, Luu T, Abood ME, Moore DH, Aldape K, Yount G (2005). Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells. Journal of Neuro-Oncology, 74(1):31-40.
- Yount G, Qian Y, Moore D, Basila D, West J, Aldape K, Arvold N, Shalev N, Haas-Kogan D (2004). Berberine Sensitizes Human Glioma Cells, but Not Normal Glial Cells, to Ionizing Radiation In Vitro. Journal of Experimental Therapeutics and Oncology, 4:137-143.
- Yount G, Taft R, West J, Moore D (2004). Possible Influence of Infrasound on Glioma Cell Response to Chemotherapy: A Pilot Study. Journal of Alternative & Complementary Medicine, 10(2):47-250.
- Yount G, Solfvin J, Moore D, Schlitz M, Reading M, Aldape K, Qian Y, (2004). In vitro test of external Qigong. BioMed Central Complementary and Alternative Medicine (15).
- Yount G, Afshar G, Ries S, Korn M, Shalev N, Basila D, McCormick F and Haas-Kogan D (2001). Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells. Oncogene, 20(22): 2826-2835.
- Yount GL, Levine KS, and Israel MA (1999). Fas (APO-1/CD95) Signaling pathway is intact in radioresistant human glioma cells. Cancer Research, 59: 1362-1365.
- Yount GL, Haas-Kogan DA, Levine KS, Aldape KD and Israel, MA (1998). Ionizing radiation inhibits chemotherapy-induced apoptosis in cultured glioma cells: Implications for combined modality therapy. Cancer Research, 8: 3819-3825.
- Yount GL, Haas-Kogan DH, Vidair CA, Haas M, Dewey WC, Israel MA (1996). Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells. Cancer Research, 56: 500-506.