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    California Pacific Currents 2005

    Currents 2005 Table of Contents | Currents Main Page

    New Research Funding for California Pacific Investigators

    Federal and State  |  Foundation  |  Pharmaceutical  |  Investigator-Initiated Research


    Federal and State

    • Roman Blanco, MD: Molecular Classification of Age-Related Macular Degeneration by Gene Expression Profiling

    • Steven Cummings, MD: Osteoporosis Coordinating Center for Women's Health Initiative; Health, Aging, and Body Composition (Health ABC); Genetic Epidemiology of Osteoporosis

    • Shanaz Dairkee, PhD: Functional Analysis of Histologic Grade in Breast Cancer

    • Pierre-Yves Desprez, PhD: HLH Proteins in Prostate Cancer Cells

    • Lynda Frassetto, MD: Exercise Responses in 4 ESRD Treatments

    • Gantt Galloway, MD: Predictors of Relapse to Methamphetamine Use

    • Kenneth Laxer, MD: High Field Neuroimaging of Epilepsy

    • Ellen Levine, PhD: Quality of Life among Breast Cancer Survivors from Diverse Populations

    • James Mailhot, MD: Study of the Impact of the Outcomes Management System for Depressed Cardiac Patients (OMSDCP) upon Clinical Outcomes

    • Sean McCallister, PhD: Molecular Mechanisms of Cannabinoid Anti-tumor Activity

    • John Mendelson, MD: Bioavailability and Urinary Excretion of l-Methamphetamine; Clinical Pharmacology of 3,4-Methylenedioxy Amphetamines; Laboratory Observation of Acute MDMA Single Dose me Withdrawal

    • John Muschler, PhD: Dystroglycan in Epithelial Architecture and Function: Discovering Novel Cell-ECM Interactions in Breast Cells

    • Soon Park, MD: Destination Therapy Registry Protocol

    • Mindy Schwartz: Family Care in Chinese Americans with Diabetes

    • Jeffrey Sternberg, MD: PTSD Symptoms and Post-Traumatic Growth in Patients with Colorectal Cancer

    • Cassandra Vieten, PhD: A Mindfulness-Based Approach to Preventing Relapse

    • Susan Wolley-Levine: Improved Methods to Detect Changes in Alzheimer's disease Using MRI/MRSI; Prediction of Cognitive Decline with MRI and MRSI

    • Li-Xi Yang, MD, PhD: Targeted Chemoradiosensitization of Prostate Cancer; Improved Chemoradiotherapy of Lung Cancer

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    Foundation

    • Armin Akhavan, PhD: Sub-cellular Mechanisms Involved in Biogenesis and Secretion of Apolipoprotein B

    • Eric Beatie, PhD: "TNF±'s Influence on the Trafficking of AMPA Receptors in Hippocampal Neurons, Cortical Neurons, and Spinal Cord Motorneurons: A Connection between Inflammation in ALS and Motor Neuron Excitoxicity?"

    • Steven Cummings, MD: Hormones, Risk factors, and Risk of ER- Breast Cancer in Postmenopausal Women (and Comparison with the Association with ER+ Cancer)

    • William Goodson, MD: A Study of Methods to Record Clinical Breast Examination (CBE)

    • Jian Liu, PhD: Identification of a Common Molecular Signature in ALS; Mechanisms of Spinal Cord Mitochondria Dysfunction in Mutant SOD1-Mediated ALS

    • John Muschler, PhD: Discovering Novel Cell-ECM Interactions in Breast Cells

    • Thomas Nuckton, MD: Assessment of the NICO® Monitor in Mechanically Ventilated Patients

    • Robert Popper, MD: Retrospective Analysis of the Clinical Course of Patients with Eisenmenger's Syndrome

    • Cassandra Vieten, PhD: Parenting Education That Includes Mindfulness Techniques for Women with a History of Depression

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    Pharmaceutical

    • Ari Baron, MD: Trial of Patient-Specific Vaccination with Conjugated Follicular Lymphoma-Derived Idiotype (FNHLId1) with Local GM-CSF in First Complete Remission; Study of CG1940 Versus Docetaxel and Prednisone in Patients with Metastatic Hormone-Refractory Prostate Cancer who are Chemotherapy-Naive

    • Maurizio Bonacini, MD: A Pharmacokinetic Study to Assess Nevirapine Levels in HIV Infected Patients with Impaired Hepatic Function

    • Michael Borah, MD: Study to Document the Efficacy, Safety and Tolerability of Long-Term Administration of RO0503821 in Patients with Chronic Renal Anemia

    • Bruce Brent, MD: JOSTENT Graft Master Coronary Stent Graft and Delivery System Application for Continuation of Humanitarian Device Exemption Status; Drug-Eluting Stents Cover Registry Protocol

    • Christopher Brown, MD: Safety and Efficacy of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) Administration in Subjects with Severe Community-Acquired Pneumonia; Efficacy and Safety of Epoetin Alfa in Critically Ill Subjects

    • David Busch, MD: Micafungin (FK463) vs. Caspofungin as Antifungal Treatment in Patients with Invasive Candidiasis or Candidemia

    • Natalie Bzowej, MD: A Phase 2B Study of Merimepodib in Combination with Pegylated Interferon Alfa-2a (Pegasys) and Ribavirin in Subjects with Chronic Genotype 1 Hepatitis C Non-Responsive to Prior Therapy with Pegylated Interferon Alfa and Ribavirin; Utility Weights for Health States Resulting from Chronic Hepatitis B Infection; A Randomized, Phase IIb Clinical Trial to Evaluate the Safety and Antiviral Activity of NM283 in Patients with Chronic Hepatitis C Who have Previously Failed to Respond to Standard Therapy; A Randomized, Open-Label Trial of Telbivudine (LdT) versus Adefovir Dipivoxil in Adults with HBeAg-Positive, Compensated Chronic Hepatitis B; A Prospective, Randomized, Multicenter, Open-Label, Comparative Safety and Efficacy Study of Prophylactically Administered Pegylated Interferon alfa-2a (Pegasys? Plus Ribavirin vs. No Prophylaxis Following Liver Transplantation for Hepatitis C

    • Steven Cummings, MD: LIFT Study: Clinical Trial of the Effects of Tibolone on the Incidence of New Vertebral Fractures in Osteoporotic Postmenopausal Women; Genetic Predictors of Tamoxifen Response

    • Todd Frederick, MD: Continuous Plasma Filtration with Sorbent Adsorbent Detoxification Utilizing the HemoLife Medical, Inc. HLM-100 Column and the HLM-200 Plasma Filter for the Treatment of Episodic Type C Hepatic Encephalopathy in Subjects with Decompensated Cirrhosis

    • Robert Gish, MD: Identification of a Molecular Signature from Peripheral Blood that Predicts Interferon Response in Hepatitis C Infection; Study of a Caspase Inhibitor in Hepatitis C Patients; Comparison of the Safety and Efficacy of Viramidine to Ribavirin in Treatment Naïve Patients with Chronic Hepatitis C

    • Steven Hao, MD: OPTIMIZER System with Active Fixation Leads in Subjects with Heart Failure Resulting from Systolic Dysfunction: Fixation Leads in Subjects with Heart Failure; Evaluation of Riata Integrated and Dedicated Bipolar Leads with CRT Devices; Evoked Response Acquisition During Acute Hospitalization in Heart Failure Patients

    • Karen Hardy, MD: Study of MEDI-524 (Numax™), an Enhanced Potency Humanized Respiratory Syncytial Virus (RSV) Monoclonal Antibody, for the Prophylaxis of Serious RSV Disease in High-Risk Children

    • Jonathan Katz, MD: An Efficacy Study of Donepezil in the Treatment of Cognitive Impairment in Patients with Amyotrophic Lateral Sclerosis (ALS)

    • Alan Kramer, MD: Study of AMG 706 in Subjects with Advanced Gastrointestinal Stromal Tumors (GISTs) Who Developed Progressive Disease or Relapsed While on Imatinib Mesylate

    • Kenneth Laxer, MD: Safety and Tolerability of Intravenous SPM 927 as Replacement for Oral SPM 927 in Subjects with Partial Seizures with or without Secondary Generalization

    • Gary Milechman, MD: Rimonabant 20-mg od, for inhibition of Atherosclerosis Progression Assessed by IVUS (Intra Vascular UltraSounds), in Overweight Patients with Clustering Risks Factors

    • Robert Miller, MD: AEOL 10150 Administered by Subcutaneous Injection in Patients with Amyotrophic Lateral Sclerosis

    • David Minor, MD: Retrospective Study of 38 Patients Treated with Biochemotherapy for Metastatic Melanoma at CPMC: An Analysis of Dose Intensity; Study of Induction Temozolomide Concurrent Biochemotherapy followed by Prophylactic Cranial Irradiation/Temozolomide and Maintenance Biotherapy in Responding Patients with Metastatic Melanoma; Study Evaluating the Anti-Tumor Activity of SB-485232, rhIL-18, Administered as Five Daily Intravenous Infusions Every 28 Days in Subjects with Previously Untreated Metastatic Melanoma(SB-485232/006)

    • V. Ram Peddi, MD: Efficacy and Safety of FK778 Compared with Standard Care in Renal Transplant Recipients with Untreated Biopsy-Diagnosed BK Nephropathy; Safety and Efficacy of Induction Agents Alemtuzumab (CAMPATH 1H), Basiliximab (Simulect) or Rabbit Anti-Thymocyte Globulin (thymoglobulin) in Combination with Tacrolimus (Prograf), Mycophenolate Mofetil (cellcept) and a Rapid Steroid Withdrawal in Renal Transplant Recipients; OPTIMA: Optimizing Prograf Therapy in Maintenance Allograft; Safety and Tolerability of Myfortic, in Combination Neoral of Tacrolimus in Renal Transplant with GI Intolerance; Everolimus for Maintenance Patients Completing Therapy in RAD Trials in Solid Organ Transplantation; Study of 2 Dose Levels of CP-690,550 Administered Concomitantly with IL-2 Receptor Antagonist Induction Therapy, Mycophenolate Mofetil (MMF) and Corticosteroids (CS) Versus a Tacrolimus-Based Immunosuppressive Regimen for the Prevention of Allograft Rejection in de Novo Renal Allograft Recipients; Study to Evaluate the Efficacy and Safety of Early Calcineurin Inhibitor Withdrawal in Recipients of Primary Renal Allografts Maintained Long-Term on Mycophenolate Mofetil

    • Robert Rodvien, MD: Study of the Effects of Antithrombotic Drugs on Ex-Vivo Platelet Function

    • William Snape, MD: Study of Sargramostim (Leukine) in Patients with Active Crohn's Disease and Prior Treatment Response to Sargramostim; LEUKINE (Sargramostim), A Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), in Active Crohn's Disease

    • Bertrand Tuan, MD: Study of XL 119 Versus 5 Fluorouracil (5-FU) plus Leucovorin (LV) in Subjects with Advanced Biliary Tumors Not Amenable to Conventional Surgery

    • Susan Wooley-Levine: A Novel System to Assess Neurocognitive Function in the Elderly

    • Laurence Yee, MD: Study of Alvimopan for the Management of Postoperative Ileus

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    Investigator-Initiated Research

    • Paul Aronowitz, MD: Medical Humanities in an Internal Medicine Residency Program

    • Thomas Baudendistel, MD: Predicting Primacy Care Competency: Correlating Exam Scores with Clinical Performance; Does Industry Sponsorship Influence the Quality of Medical Grand Rounds in a Community Hospital?

    • Maurizio Bonacini, MD: The Role of Splenic Embolization for Severe Thrombocytopenia in Patients with Portal Hypertensive Splenomegaly; Liver Disease in Asians: Comparison with Other Ethnic Groups

    • Helen Bremford, RN: Evaluation of Sutter Health's eICU

    • Frank Delen, MD: Resting Energy Expenditures and MELD Scores in Pre-liver Transplant Patients

    • Andrew Freinkel, MD: A Retrospective Study of 330 Patients Treated with Nutritional Supplements for Glioblastoma

    • Kanwar Gill, MD: Racial Disparity in the Diagnosis of Colorectal Cancer in Individuals Less than 50 Years of Age

    • Robert Gish, MD: Alcohol Dependence and Liver Transplantation; Autoimmune Database Review

    • Luanne Linnard-Palmer: Effects of Therapeutic Massage on Reports of Pain Perception in Cancer Patients

    • Adil Wakil, MD: Role of Keratin Mutations as Susceptibility Genes for Liver Disease in African-Americans

    • Donna Wiggins, MD: Comparison of Pregnancy Outcomes in Donor Egg vs. Standard IVF Pregnancies

    • Daniella Zipkin, MD: Pharmaceutical Industry Relations Resident Survey

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