Currents 2004 Table of Contents | Currents Main Page
New Research Funding for California Pacific Investigators
The Research Institute is proud to announce two grants of special significance from the National Institutes of Health, both awarded during 2003:
- A Consortium to Study the Genetics of Longevity Total award is $17,735,500 for five years, by the National Institute of Aging. Principal Investigators are Steven Cummings, MD, and Warren Browner, MD.
- Methamphetamine Pharmacotherapy Development Center Total award is $5,840,183 for four years, by the National Institute of Drug Abuse. Principal Investigators are John Mendelson, MD, and Gantt Galloway, PharmD.
Eric Beattie, PhD: Tumor Necrosis Factor (TNF) Alpha Signaling: Effects on a-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid (AMPA) Receptor Location
Steven Cummings, MD: Sex Hormones, Related Polymorphisms and Cognitive Decline; Osteoporotic Fractures in Men; Risk Factors for Hip and Colles’ Fractures
Pierre Desprez, PhD: HLH Proteins in Prostate Cancer Cells
Shelley Gordon, MD: Molecular Epidemiology of Community Methicillin Resistance Staphylococcus aureus
Dieter Gruenert, PhD: Generation of a Cystic Fibrosis Pig by Small Fragment Homologous Replacement and Nuclear Transfer
Ernest Haeusslein, MD: National Hospital Ambulatory Medical Care Study
Steven Katznelson, MD: Evaluation of Immune Globulin Intravenous (Human), 10%, Manufactured by Chromatography (IGIV-C-C, 10%), as an Agent to Reduce Anti-HLA Antibodies and Improve Transplant Results in Cross Match + Living Donor Kidney Allograft Recipients
David King-Stephens, MD: Qualitative Neuropathological Description with Cell Counts and Immunohistochemical Analysis of Peptide Receptors and Amino Acid Transporters of Epileptogenic Human Transport
Ellen Levine, PhD, MPH: Quality of Life among Breast Cancer Survivors from Diverse Populations
Robert Miller, MD: Gene Expression in Human Macrophages from Patients with ALS; Amyotrophic Lateral Sclerosis Patient Care Database; Clinical Trial of High Dose Coenzyme Q10 in ALS Patients
Mindy Schwartz, RN: Diabetes, Mood and Management Assessment Project (D-MMAP)
Li-Xi Yang, MD, PhD: Targeted Chemoradiosensitization of Prostate Cancer
Garrett Yount, PhD: Novel Migration Behavior of Breast Cancer Cells May Predict Metastatic Potential
State and Local Government Funding
Sylvia Fong, PhD: FK506-Binding Protein (FKBP) Proteins as Molecular Targets in Breast Cancer Therapy
John Muschler, PhD: Discovering Novel Cell Extracellular Matrix (ECM) Interactions in Breast Cells
Foundation Funding
Lola Barnes, RN: The Use of Complementary Health Modalities in a Higher Risk Prenatal Population
Stephen Becker, MD: (CRCLE Project) Biobank for HIV Evaluation (BHIVE)
Christopher Brown, MD: California Intensive Care Outcomes Project (CALICO) within the California Pacific Medical Center
Steven Cummings, MD: (CRCLE Project) Obtaining and Archiving Blood in the Breast Health Cohort; Clinical Evaluation of Breast Single X-Ray Absorptiometry
Deborah Gelinas, MD: A Pilot Study of HOPE in ALS and Other Chronic Neurological Diseases
Daniel Goodman, MD: Aphakic Intraoperative Refraction for Intraocular Lens Calculation
William Goodson, MD: Palpation in the Diagnosis of Breast Cancer
Dieter Gruenert, PhD: Targeted Cystic Fibrosis Transmembrane Regulator (CFTR) Replacement on Cystic Fibrosis Airway Epithelial Cells; Sequence-Specific Modification of Human Beta-Globin DNA
Jill Ley, RN, MS: Are HIV Patients at Higher Risk for Complications Following Cardiac Surgery?
Fred Margolin, MD: Benign Papillary Breast Lesions Diagnosed at Large Core Needle Biopsy: Correlation with Surgical Pathology and Imaging Follow-Up; Comparative Performance of Specialists and General Radiologists in Screening and Diagnostic Mammography
Robert Miller, MD: Amyotrophic Lateral Sclerosis Web-Based Patient Care Database; Gene Expression in Human Macrophages from Patients with ALS
Thomas Musci, MD: Prenatal Carrier Screening for Fragile X Syndrome: A Pilot Program to Assess the Feasibility of Universal Screening
Soon Park, MD: Participation in the Mechanical Circulatory Support Device Database
William Snape, MD: (CRCLE Project) Evaluation of Patients with Nausea and Vomiting As Associated with Delayed Gastric Emptying
H. David Watts, MD: Written Emotional Disclosure for Women with Breast Cancer: A Randomized, Controlled Trial
Li-Xi Yang, MD, PhD: A Novel Chemotherapeutic Agent for Improved Therapy of Metastatic Breast Cancer
Garret Yount, PhD: Feasibility Study: Development of an Immune Recovery Model to Investigate Therapeutic Johrei
Pharmaceutical and Biotechnology Funding
Francois Antounian, MD: Evaluation of the Treatment of Chronic Elbow Tendonitis with Bipolar Radiofrequency; Computer Assisted Surgery in Total Knee Replacement Surgery
Ari Baron, MD: Study of Cetuximab, Oxaliplatin, 5-Fluorouracil, and Leucovorin vs Oxaliplatin, 5-Fluorouracil, and Leucovorin in Patients with Previously Treated Metastatic, Epidermal Growth Factor Receptor (EGFR)-Positive Colorectal Carcinoma; Targeted Study Investigating the Safety and Pharmacokinetics of Orally Administered Gallium Maltolate in Patients with Various Refractory Malignancies
Stephen Becker, MD: Safety and Efficacy of Autologous CD34+Hematopoietic Progenitor Cells Transduced with Placebo or an Anti-HIV-1Ribozyme (OZ1) in Patients with HIV-1 Infection; Steady-State Pharmacokinetics of Once Daily Ritonavir-Boosted Saquinavir and Once-Daily Saquinavir and Atazanavir in Adults not Infected with HIV: Atazanavir-Saquinavir Pharmacokinetic Research Endeavor (ASPIRE)
Kenneth Binmoeller, MD: Evaluation of Medtronic GatekeeperTM System in the Treatment of Subjects with Esophageal Reflux Disease (GERD)
Neal Birnbaum, MD: An Epidemiological Study of Point Prevalence of Undiagnosed Pulmonary Artery Hypertension in Patients with Connective Tissue Disease at Secondary Healthcare Level of Community-Based Rheumatologists
Maurizio Bonacini, MD: Evaluation and Treatment of Anemia Post Liver Transplant Using Erythropoietin
Michael Borah, MD: TARGET: Treatment Strategies to Achieve Recommended Kidney Disease Outcomes Quality Initiative Goals in End Stage Renal Disease Patients on Cinacalcet; Evaluation of the Efficacy of StaphVAX, a Bivalent Staphylococcus aureus Glycoconjugate Vaccine in Adults on Hemodialysis; Efficacy and Safety of RO0503821 when Administered Intravenously for the Maintenance Treatment of Anemia in Patients with Chronic Kidney Disease Who Are on Dialysis
Natalie Bzowej, MD: Efficacy and Safety of 16-Week vs 24-Week Treatment with PEGASYS in Combination with Copegus in Interferon-Naïve Patients with Chronic Hepatitis C Genotype 2 or 3 Virus Infection; Effects of Titrated Oral Tolvaptan Tablets in Patients with Hyponatremia; Combination of Entecavir Plus Adefovir, Entecavir Monotherapy and Adefovir Monotherapy in Adults with Chronic Hepatitis B and Additional Pharmacogenetics Blood Sample
Steven Cummings, MD: Zoledronic Acid in the Treatment of Osteoporosis in Postmenopausal Women
David Curtis, MD: Safety and Efficacy of Infliximab in Subjects with Giant Cell Arthritis
Deborah Gelinas, MD: Evaluation of the Safety and Efficacy of Donepezil Hydrochloride in Patients with Severe Alzheimer’s Disease Followed by a 12-Week Open Label Extension Period
Robert Gish, MD: Study to Evaluate the Pharmacokinetics of Tacrolimus or Cyclosporine When Co-Administered with Adefovir Dipivoxil 10 mg to Patients Post Liver Transplantation; Study to Compare the Anti-Viral Efficacy, Pharmacokenetics, and Safety of HepeX-B, a Mixture of Two Monoclonal Antibodies, as Compared to Hepatitis B Immune Globulin in Patients Who Have Received Hepatic Allografts for Treatment of End Stage Liver Disease Due to Hepatitis B Virus Infection; A Study of the Safety and Efficacy of PEG-Alfacon and Ribavirin in HCV-Infected Patients Who Have Failed Previous Pegylated Interferon Plus Ribavirin Therapy; Study to Investigate Safety, Tolerability and Effects of Tezosentan on Portal Pressure in Patients with Portal Hypertension Secondary to Cirrhosis; Study in Patients with Compensated Cirrhosis Due to Chronic Hepatitis C Who Are Non-Responders to Prior Interferon Alfa or Interferon Alfa + Ribavirin Therapy, Comparing Treatment with Thymosin Alpha 1 + PEG Interferon Alfa 2a with PEG Interferon Alfa 2a + Placebo
Daniel Glaubiger, MD: Safety and Efficacy of Benzydamine Hydrochloride 0.15% Oral Rinse Including a Separate Open-Label Standard of Care Arm in Subjects with Radiation-Induced Oral Mucositis
Steven Goldman, MD: Clinical Trial Comparing the Safety and Efficacy of Veronate vs Placebo for the Prevention of Nosocomial Staphylococcal Sepsis in Premature Infants
Kathleen Grant, MD: Novel Epothilone BMS-247550 Plus Capecitabine vs Capecitabine Alone in Patients with Advanced Breast Cancer Previously Treated with or Resistant to Anthracycline and Who Are Taxane Resistant
Garrett Hisatake, MD: A National Registry of Patients with Hepatocellular Carcinoma
Peter Hui, MD: The Acuity Trial: A Randomized Comparison of Agiomax (Bivalirudin) vs Lovenox/Clexane (Enoxaparin) in Patients Undergoing Early Invasive Management for Acute Coronary Syndromes without ST-Segment Elevation; Coronary Artery Intravascular Ultrasound Evaluation of Anti-Atherosclerotic Efficacy, Safety and Tolerability of Fixed Combination P - 529,414/ Atorvastatin Administered Orally, Once Daily for 24 Months, Compared with Atorvastatin Alone, in Subjects with Angiographically Documented Coronary Heart Disease; Safety and Efficacy of Intravenous MCC-135
as an Adjunct to Standard Therapy with Primary Percutaneous Coronary Intervention in Patients Diagnosed as Having an ST Elevation Acute Myocardial Infarction
David King-Stephens, MD: Efficacy and Safety of SPM 927 (400 and 600 mg/day) as Adjunctive Therapy in Subjects with Partial Seizures with or without Secondary Generalization
Kenneth Laxer, MD: Effect of Donepezil on Cognitive Function in Epilepsy
Robert Miller, MD: Study of Four Oral Doses of TCH346 in Patients with ALS
Soon Park, MD: Clinical Investigation of DeBakey Ventricular Assist Device (VAD) with Comparison to Performance Goal to Establish Safety and Effectiveness of the Device as a Left Ventricular Assist Support in Patients Awaiting Cardiac Transplantation; Safety and Efficacy of the DeBakey VAD as Destination Therapy in Patients with End-Stage Heart Failure
V. Ram Peddi, MD: Study of Transplant-Related Anemia Treated with Aranesp (STRATA); Safety and Efficacy of Prograf (Tacrolimus)/MMF, Modified Release (MR) Tacrolimus/MMF and Neoral (Cyclosporin)/MMF in De Novo Kidney Transplant Recipients; Safety, Tolerability and Efficacy of Certican (RAD001) with Simulect, and Corticosteroids vs Tacrolimus in De Novo Renal Transplant Recipients; Study Comparing Thymoglobulin in a Rapid Discontinuation of Corticosteroids Protocol with Standard Corticosteroid Therapy in Living Donor Renal Transplantation Using Mycophenolate Mofetil and Tacrolimus Maintenance Therapy
William Snape, MD: Dosing Regimens of Alosetron in Female Subjects with Severe Diarrhea-Predominant Irritable Bowel Syndrome Who Have Failed Conventional Therapy; Study of YM443 in Subjects with Functional Dyspepsia; Study of Enteryx for the Treatment of Gastroesophageal Reflux Disease (GERD)
Bertrand Tuan, MD: ALIMTA (Pemetrexel) Alone or in Combination with Cisplatin for Patients with Malignant Mesothelioma
Adil Wakil, MD: Efficacy and Safety of Entecavir vs Adefovir in Subjects Chronically Infected with Hepatitis B Virus with Evidence of Lamivudine Resistance and Hepatic Decompensation