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    Cardiac Stress Test: Nuclear Myocardial Perfusion Imaging (MPI) with Dipyridamole (Persantine®)

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    What is a Cardiac Stress Test (MPI) with Dipyridamole?

    A cardiac stress test with Myocardial Perfusion Imaging (MPI) is a non-invasive test (no surgery or cutting skin). This test takes four (4) hours and is done in three (3) parts with breaks between each part. A cardiac stress test with MPI is done to study the blood flow to your heart during stress and at rest. This test helps your doctor diagnose coronary artery disease (CAD). This test may also be called the "Persantine® stress test."

    • If you are pregnant, breastfeeding, have asthma or chronic obstructive pulmonary disease (COPD), or are taking theophylline or caffeine-containing drugs, you must talk to your doctor before the test.


    • For women weighing over 200 pounds or for men weighing over 250 pounds: pictures of your heart are taken on two (2) separate days. You schedule the second appointment on the first day of your test.

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    Before the Test

    • DO NOT eat or drink 6 hours before the test except for plain drinking water: You may drink water anytime.


    • No food or drink with caffeine for 24 hours before the test: No coffee, tea, sodas with caffeine, or chocolate.


    • Bring the requisition form signed by your doctor to your appointment or we may not be able to do your test.


    • About your medicines: Check with your doctor about which of your regular medicines to take or stop before the test.


    • Wear comfortable, loose clothing (pants or shorts). You are asked to undress from the waist up and wear a short gown for privacy and comfort.

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    During the Test

    Part 1: Cardiology

    • First, electrodes are placed on your chest to monitor your heart rhythm. A blood pressure cuff is wrapped around your arm.


    • An intravenous (IV) line (a small plastic tube with a needle) is placed in your arm or hand.


    • Next, the nurse or doctor puts a medicine called Dipyridamole into your IV. Dipyridamole increases the blood flow to your heart by expanding your blood vessels. This medicine is similar to the effect of exercising. Your heart activity and blood pressure are monitored.


    • You may feel slightly light-headed or flushed after the medicine. Some patients may have mild chest pain. If you feel any of these symptoms, please tell your nurse or doctor.


    • Near the end of the test, a small amount of a radioactive material called a "tracer" is put in the IV. Note: Radiation exposure from this test is very small, about 700 millirads, which is about the same as from living in San Francisco for two years.


    • Next, another medicine, called Aminophylline® is put into the IV. This medicine stops the action of Dipyridamole and reduces any symptoms you may feel.


    • Your heart rhythm and blood pressure are monitored.


    • You go to Nuclear Medicine for the second part of the test.
    Part 2: Nuclear Medicine

    • You lie down on an "imaging" table with your arms above your head. A camera moves around your body taking pictures of your heart. It is important to lie very still and to breathe normally. This takes about 30 minutes.


    • Another tracer may be put into your IV to take pictures of your heart at rest.
    Part 3: Nuclear Medicine

    • You need to return to Nuclear Medicine 30-90 minutes later for more pictures of your heart at rest.

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    After the Test

    • You can eat and drink normally. Eating and drinking fluids help remove the tracer from your body.


    • You can go back to your regular medicines.


    • You may drive yourself home after the test.


    • Return to your normal activities (for example, you may return to work).


    • The results of your test are available in a few days. Please remember, it is your doctor, not the staff, who goes over your test results with you.

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    Frequently Asked Questions


    Question: How long does the test take?
    Answer: This test is done in 3 parts over four (4) hours. There are breaks between each part of the test.

    Question: Can I drive home after my test?
    Answer: Yes, you may drive yourself home after this test.

    Question: Can I return to work after my test?
    Answer: Yes, you may return to your normal activities after this test (for example, you may return to work).


    Produced by the Center for Patient and Community Education in association with the staff and physicians at California Pacific Medical Center. Last updated: 8/07


    Funded by: A generous donation from the Mr. and Mrs. Arthur A. Ciocca Foundation.

    Note: This information is not meant to replace any information or personal medical advice which you get directly from your doctor(s). If you have any questions about this information, such as the risks or benefits of the treatment listed, please ask your doctor(s).

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