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    Solving the Mystery of Dementia

    2013 Annual Report on Philanthropy – CPMC FoundationGreg Tranah, Ph.D. (center) with Mike Rowbotham, M.D., scientific director of CPMC Research Institute

    Greg Tranah, Ph.D. (center) with Mike Rowbotham, M.D.,
    scientific director at CPMC Research Institute.


    CPMC Research Institute scientist Greg Tranah, Ph.D., is among a select group of investigators examining how mutations in mitochondrial DNA (mtDNA) can lead to cognitive decline and dementia. The research study and acquisition of a DNA sequencer for the project were funded by CPMC Foundation at the recommendation of its Research and Education Leadership Council.

    “We know that mitochondrial dysfunction is a hallmark of neurodegenerative diseases like dementia,” says Dr. Tranah. “The new DNA sequencer will allow us to comprehensively assess a large amount of genetic information, which could ultimately lead to a screening approach for identifying those most at risk of developing dementia. It could also help personalize care by indicating which patients would respond best to treatments that we know target mitochondria.”

    Research That Personalizes Care